Refeyn, a leader in mass photometry technology, expands the analytical possibilities for high concentration samples by MassFluidix HC. The new microfluidic system enhances protein analysis workflows for the study of weak protein-protein interaction by mass photometry.
The new system is compatible with Refeyn’s TwoMP mass photometres and will allow for the accurate measurement of low-affinity biomolecular interactions through rapid dilution, such that the interaction state at micromolar concentrations is captured before the disruption of the equilibrium. Refeyn is building technology for researchers as they can now analyze samples with concentrations of up to 90 µM, a 100-fold increase on previous capability.
The MassFluidix HC systems provides precise and rapid dilution of up to 10,000-fold in milliseconds, facilitation detection of low-affinity complexes that was not previously observed. It consists of two parts: the microfluidics device, and a consumable chip for immediate analysis allowing for the sample to reach the observation window within <50 ms of the beginning of the dilution process.
Essentially, this approach builds up the speed and simplicity already offered by mass photometry and opens us new applications such as transient binding and oligomerization, all label-free, in solution, and at the single-molecule level.
It is interesting to highlight that the introduction of this new system builds upon Refeyn’s commitment to meeting the needs of its customers and addressing the unique challenges of protein research through the expansion of capability posed by mass photometry. The MassFluidix HC system is an essential addition for every researcher looking to expand the potential of mass photometry and streamlining the protein analysis workflow.
Systems for Research is a proud vendor of Refeyn and commends it on the development of its latest system as it keeps up with their shared goal of empowering research and innovation. As a leader in mass photometry, Refeyn is opening doors for research and unveiling greater potential into the world of innovation through mass photometry.
Systems for Research is proud to announce the release of a new white paper titled “In Situ X-ray Approaches in Battery Research” by its leading partner, Sigray. The paper effectively highlights the development of a suite of groundbreaking lab-based x-ray tools for energy research with performance capabilities approaching that of synchrotron-based approaches.
The new paper titled “ Characterization of Virus Particles and Submicron-Sized Particulate Impurities in Recombinant Adeno-Associated Virus Drug Product” published by Boehringer Ingelheim explore the benefits of MP analysis for assessing aggregate content in AAV samples.
Although low counts for aggregates impeded a quantitative analysis, MP was affirmed as an accurate and rapid method for quantifying the genome content of empty/filled/double-filled capsids.
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The featurefindIR provides rapid, automated detection, spectroscopic measurement, and chemical identification of microplastics and other particles, significantly improving the productivity of measurement and providing a basis for measurements of large number of samples in applications including but not limited to microplastics, defect contamination and cells analysis, as well as many other sample types.