Refeyn unveils it's latest innovation, the MassFluidix High Concentration (HC) microfluidic system

October 18, 2023 2 min read

Refeyn unveils its latest innovation, the MassFuidix High Concentration (HC) microfluidic system.


Refeyn, a leader in mass photometry technology, expands the analytical possibilities for high concentration samples by MassFluidix HC. The new microfluidic system enhances protein analysis workflows for the study of weak protein-protein interaction by mass photometry. 


The new system is compatible with Refeyn’s TwoMP mass photometres and will allow for the accurate measurement of low-affinity biomolecular interactions through rapid dilution, such that the interaction state at micromolar concentrations is captured before the disruption of the equilibrium. Refeyn is building technology for researchers as they can now analyze samples with concentrations of up to 90 µM, a 100-fold increase on previous capability. 


The MassFluidix HC systems provides precise and rapid dilution of up to 10,000-fold in milliseconds, facilitation detection of low-affinity complexes that was not previously observed. It consists of two parts: the microfluidics device, and a consumable chip for immediate analysis allowing for the sample to reach the observation window within <50 ms of the beginning of the dilution process.



Rapid dilution of highly concentrated samples


Essentially, this approach builds up the speed and simplicity already offered by mass photometry and opens us new applications such as transient binding and oligomerization, all label-free, in solution, and at the single-molecule level. 


It is interesting to highlight that the introduction of this new system builds upon Refeyn’s commitment to meeting the needs of its customers and addressing the unique challenges of protein research through the expansion of capability posed by mass photometry. The MassFluidix HC system is an essential addition for every researcher looking to expand the potential of mass photometry and streamlining the protein analysis workflow. 


Systems for Research is a proud vendor of Refeyn and commends it on the development of its latest system as it keeps up with their shared goal of empowering research and innovation. As a leader in mass photometry, Refeyn is opening doors for research and unveiling greater potential into the world of innovation through mass photometry.